If you look up all of the occurences of the word perish (occurs around 30 times), only about a handful of them can be interpreted this way. Of those instances, compared with the normal usage of the word, I would say that they still refer to death. Like when Paul refers to "them that perish". I think he means that they are dyeing, with no hope of life (unless they repent). They are recieving the wages of sin.I'll put in my 2 cents on this point. The word "perish" as it is used in John 3:16 does not refer to physical death. It refers to someone who is overcome in their own sinfulness. Someone can be "dead" in sin. Just like this woman....
Look at Peters use of the word in 2 Peter 3:9.
2Pe 3:9 The Lord is not slack concerning his promise, as some men count slackness; but is longsuffering to us-ward, not willing that any should perish, but that all should come to repentance.
The Lord is here said to be waiting for the day of judgement, because He wishes that none should perish. He is giving people time to repent, because when He comes back, that's it. Then comes the judgement. If "perish" meant simply to be unhappy, bitter, etc in this life, then this verse doesn't make much sense.
I am not saying that feeling those things is not a part of "perishing", and that feeling the opposite of those things is not part of eternal life, but thats not all.
God bless,